Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Aminopterin Sodium
Synonyms
Definitions

The sodium salt of a pterin derivative with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)
ID

http://purl.obolibrary.org/obo/NCIT_C74554
CAS_Registry

58602-66-7
Chemical_Formula

C19H18N8O5.2Na
code

C74554
Contributing_Source

FDA
definition

The sodium salt of a pterin derivative with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)
FDA_UNII_Code

FZU1QI13O9
Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C235
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909
label

Aminopterin Sodium
Legacy Concept Name

Aminopterin_Sodium
Maps_To

Aminopterin Sodium
Preferred_Name

Aminopterin Sodium
prefixIRI

NCIT:C74554
prefLabel

Aminopterin Sodium
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
UMLS_CUI

C0282048
subClassOf

http://purl.obolibrary.org/obo/NCIT_C511

http://purl.obolibrary.org/obo/NCIT_C2153
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