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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Pentamidine | |
| Synonyms |
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| Definitions |
A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C731 |
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| ALT_DEFINITION |
The active ingredient in a drug used to treat infections caused by certain microorganisms. It is also being studied in the treatment of melanoma. It prevents DNA from being copied and may kill cancer cells. It is a type of antifungal agent, a type of antiprotozoal agent, and a type of PRL phosphatase inhibitor.
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| CAS_Registry |
100-33-4
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| CHEBI_ID |
CHEBI:45081
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| Chemical_Formula |
C19H24N4O2
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|
| code |
C731
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| Contributing_Source |
CTRP FDA
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|
| definition |
A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. (NCI04)
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| Display_Name |
Pentamidine
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| FDA_UNII_Code |
673LC5J4LQ
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
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| label |
Pentamidine
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|
| Legacy Concept Name |
Pentamidine
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| NCI_Drug_Dictionary_ID |
40324
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| NSC Number |
9921
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| PDQ_Closed_Trial_Search_ID |
40324
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| PDQ_Open_Trial_Search_ID |
40324
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| Preferred_Name |
Pentamidine
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| prefixIRI |
NCIT:C731
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| prefLabel |
Pentamidine
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0030863
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| subClassOf |
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