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Biological and Environmental Research Ontology
| Preferred Name | Artesunate | |
| Synonyms |
|
|
| Definitions |
A water-soluble, semi-synthetic derivative of the sesquiterpine lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities. Upon hydrolysis of artesunate's active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered radicals form, which have been shown to damage and kill parasitic organisms. Additionally, in vitro studies demonstrate that this agent induces DNA breakage in a dose-dependent manner. Artesunate has also been shown to stimulate cell differentiation, arrest the cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis through mitochondrial and caspase signaling pathways. Artemisinin is isolated from the plant Artemisia annua. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C73005 |
|
| CAS_Registry |
88495-63-0
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|
| CHEBI_ID |
CHEBI:63918
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|
| Chemical_Formula |
C19H28O8
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|
| code |
C73005
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|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A water-soluble, semi-synthetic derivative of the sesquiterpine lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities. Upon hydrolysis of artesunate's active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered radicals form, which have been shown to damage and kill parasitic organisms. Additionally, in vitro studies demonstrate that this agent induces DNA breakage in a dose-dependent manner. Artesunate has also been shown to stimulate cell differentiation, arrest the cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis through mitochondrial and caspase signaling pathways. Artemisinin is isolated from the plant Artemisia annua.
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| Display_Name |
Artesunate
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| FDA_UNII_Code |
60W3249T9M
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Artesunate
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|
| Legacy Concept Name |
Artesunate
|
|
| Maps_To |
Artesunate
|
|
| NCI_Drug_Dictionary_ID |
617258
|
|
| PDQ_Closed_Trial_Search_ID |
617258
|
|
| PDQ_Open_Trial_Search_ID |
617258
|
|
| Preferred_Name |
Artesunate
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|
| prefixIRI |
NCIT:C73005
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|
| prefLabel |
Artesunate
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0052432
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| subClassOf |
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