Preferred Name |
Pioglitazone |
|
Synonyms |
|
|
Definitions |
An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C71633 |
|
ALT_DEFINITION |
A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth) from developing into cancer. It is a type of thiazolidinedione. |
|
CAS_Registry |
111025-46-8 |
|
CHEBI_ID |
CHEBI:8228 |
|
Chemical_Formula |
C19H20N2O3S |
|
code |
C71633 |
|
Contributing_Source |
CTRP FDA |
|
definition |
An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. |
|
Display_Name |
Pioglitazone |
|
FDA_UNII_Code |
X4OV71U42S |
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Has_Salt_Form | ||
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
Is_Value_For_GDC_Property | ||
label |
Pioglitazone |
|
Legacy Concept Name |
Pioglitazone_Base |
|
Maps_To |
Pioglitazone |
|
Preferred_Name |
Pioglitazone |
|
prefixIRI |
NCIT:C71633 |
|
prefLabel |
Pioglitazone |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0071097 |
|
subClassOf |