loading...| Preferred Name | Fludrocortisone | |
| Synonyms |
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| Definitions |
A synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na+ permeability in cells, thereby enhancing Na+ reabsorption and water retention as well as increasing K+, H+ excretion. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C71629 |
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| ALT_DEFINITION |
A synthetic corticosteroid. It is used to replace steroid hormones normally produced by the adrenal gland. |
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| CAS_Registry |
127-31-1 |
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| CHEBI_ID |
CHEBI:50885 |
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| Chemical_Formula |
C21H29FO5 |
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| code |
C71629 |
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| Contributing_Source |
FDA |
|
| definition |
A synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na+ permeability in cells, thereby enhancing Na+ reabsorption and water retention as well as increasing K+, H+ excretion. |
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| FDA_UNII_Code |
U0476M545B |
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| in_subset | ||
| label |
Fludrocortisone |
|
| Legacy Concept Name |
Fludrocortisone_Base |
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| NSC Number |
11318 |
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| Preferred_Name |
Fludrocortisone |
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| prefixIRI |
NCIT:C71629 |
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| prefLabel |
Fludrocortisone |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0016280 |
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| subClassOf |