loading...| Preferred Name |
Omeprazole |
|
| Synonyms |
|
|
| Definitions |
A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C716 |
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| ALT_DEFINITION |
A drug that inhibits gastric acid secretion. |
|
| CAS_Registry |
73590-58-6 |
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| CHEBI_ID |
CHEBI:7772 |
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| Chemical_Formula |
C17H19N3O3S |
|
| code |
C716 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors. |
|
| Display_Name |
Omeprazole |
|
| FDA_UNII_Code |
KG60484QX9 |
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Omeprazole |
|
| Legacy Concept Name |
Omeprazole |
|
| NCI_Drug_Dictionary_ID |
42309 |
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| PDQ_Closed_Trial_Search_ID |
42309 |
|
| PDQ_Open_Trial_Search_ID |
42309 |
|
| Preferred_Name |
Omeprazole |
|
| prefixIRI |
NCIT:C716 |
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| prefLabel |
Omeprazole |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0028978 |
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| subClassOf |