Preferred Name | Octreotide | |
Synonyms |
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|
Definitions |
A synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone. |
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ID |
http://purl.obolibrary.org/obo/NCIT_C711 |
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Accepted_Therapeutic_Use_For |
Acromegaly; Diarrhea |
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ALT_DEFINITION |
A drug similar to the naturally occurring growth hormone inhibitor somatostatin. Octreotide is used to treat diarrhea and flushing associated with certain types of tumors. |
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CAS_Registry |
83150-76-9 |
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CHEBI_ID |
CHEBI:7726 |
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Chemical_Formula |
C49H66N10O10S2 |
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code |
C711 |
|
Contributing_Source |
CTRP FDA |
|
definition |
A synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone. |
|
Display_Name |
Octreotide |
|
FDA_UNII_Code |
RWM8CCW8GP |
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Has_Salt_Form | ||
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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Is_Value_For_GDC_Property | ||
label |
Octreotide |
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Legacy Concept Name |
Octreotide |
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Maps_To |
Octreotide |
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Preferred_Name |
Octreotide |
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prefixIRI |
NCIT:C711 |
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prefLabel |
Octreotide |
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PubMedID_Primary_Reference |
16917205 |
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Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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UMLS_CUI |
C0028833 |
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subClassOf |