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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Thiopental Sodium | |
| Synonyms |
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| Definitions |
The sodium salt form of thiopental, an ultrashort-acting barbituric acid derivative, with anesthetic activity. Thiopental binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C66599 |
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| CAS_Registry |
71-73-8
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| CHEBI_ID |
CHEBI:9561
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| Chemical_Formula |
C11H17N2O2S.Na
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| code |
C66599
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| Contributing_Source |
FDA
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| definition |
The sodium salt form of thiopental, an ultrashort-acting barbituric acid derivative, with anesthetic activity. Thiopental binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses.
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| FDA_UNII_Code |
49Y44QZL70
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Thiopental Sodium
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|
| Legacy Concept Name |
Thiopental_Sodium
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| Preferred_Name |
Thiopental Sodium
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| prefixIRI |
NCIT:C66599
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| prefLabel |
Thiopental Sodium
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0936073
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| subClassOf |
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