Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Spirapril Hydrochloride
Synonyms
Definitions

The hydrochloride salt form of spirapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its active metabolite spiraprilat. Spiraprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Spirapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
ID

http://purl.obolibrary.org/obo/NCIT_C66561
CAS_Registry

94841-17-5
Chemical_Formula

C22H30N2O5S2.HCl
code

C66561
Contributing_Source

FDA
definition

The hydrochloride salt form of spirapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its active metabolite spiraprilat. Spiraprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Spirapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
FDA_UNII_Code

OCC25LM897
Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C66560
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Spirapril Hydrochloride
Legacy Concept Name

Spirapril_Hydrochloride
Preferred_Name

Spirapril Hydrochloride
prefixIRI

NCIT:C66561
prefLabel

Spirapril Hydrochloride
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C1528843
subClassOf

http://purl.obolibrary.org/obo/NCIT_C247
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