loading...| Preferred Name |
Olmesartan |
|
| Synonyms |
|
|
| Definitions |
A synthetic imidazole derivative and angiotensin II receptor antagonist with antihypertensive activity. Olmesartan selectively binds to the angiotensin type 1 (AT1) receptor subtype in vascular smooth muscle and adrenal gland, thereby competing with angiotensin II for binding to the AT1 receptor. This prevents angiotensin II-induced vasoconstriction and interferes with angiotensin II-mediated aldosterone secretion, thereby decreasing aldosterone production and preventing aldosterone-stimulated sodium retention and potassium excretion. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C66253 |
|
| CAS_Registry |
144689-24-7 |
|
| CHEBI_ID |
CHEBI:48416 |
|
| Chemical_Formula |
C24H26N6O3 |
|
| code |
C66253 |
|
| Contributing_Source |
FDA |
|
| definition |
A synthetic imidazole derivative and angiotensin II receptor antagonist with antihypertensive activity. Olmesartan selectively binds to the angiotensin type 1 (AT1) receptor subtype in vascular smooth muscle and adrenal gland, thereby competing with angiotensin II for binding to the AT1 receptor. This prevents angiotensin II-induced vasoconstriction and interferes with angiotensin II-mediated aldosterone secretion, thereby decreasing aldosterone production and preventing aldosterone-stimulated sodium retention and potassium excretion. |
|
| FDA_UNII_Code |
8W1IQP3U10 |
|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Olmesartan |
|
| Legacy Concept Name |
Olmesartan |
|
| Preferred_Name |
Olmesartan |
|
| prefixIRI |
NCIT:C66253 |
|
| prefLabel |
Olmesartan |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1098320 |
|
| subClassOf |