Preferred Name |
Nebivolol |
|
Synonyms |
|
|
Definitions |
A beta-1 adrenergic receptor antagonist with antihypertensive and vasodilatory activity. Nebivolol binds to and blocks the beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. In addition, nebivolol potentiates nitric oxide (NO), thereby relaxing vascular smooth muscle and exerting a vasodilatory effect. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C66221 |
|
Accepted_Therapeutic_Use_For |
Hypertension |
|
CAS_Registry |
118457-14-0 |
|
CHEBI_ID |
CHEBI:64022 |
|
Chemical_Formula |
C22H25F2NO4 |
|
code |
C66221 |
|
Contributing_Source |
FDA |
|
definition |
A beta-1 adrenergic receptor antagonist with antihypertensive and vasodilatory activity. Nebivolol binds to and blocks the beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. In addition, nebivolol potentiates nitric oxide (NO), thereby relaxing vascular smooth muscle and exerting a vasodilatory effect. |
|
FDA_UNII_Code |
030Y90569U |
|
Has_Salt_Form | ||
in_subset | ||
label |
Nebivolol |
|
Legacy Concept Name |
Nebivolol |
|
Preferred_Name |
Nebivolol |
|
prefixIRI |
NCIT:C66221 |
|
prefLabel |
Nebivolol |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0068475 |
|
subClassOf |