loading...| Preferred Name | Methohexital Sodium | |
| Synonyms |
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| Definitions |
The sodium salt of methohexital, a rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C66117 |
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| CAS_Registry |
309-36-4 |
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| CHEBI_ID |
CHEBI:6834 |
|
| Chemical_Formula |
C14H17N2O3.Na |
|
| code |
C66117 |
|
| Contributing_Source |
CPTAC FDA |
|
| definition |
The sodium salt of methohexital, a rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses. |
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| FDA_UNII_Code |
60200PNZ7Q |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C156952 |
|
| label |
Methohexital Sodium |
|
| Legacy Concept Name |
Methohexital_Sodium |
|
| Preferred_Name |
Methohexital Sodium |
|
| prefixIRI |
NCIT:C66117 |
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| prefLabel |
Methohexital Sodium |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0304448 |
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| subClassOf |