loading...| Preferred Name |
Methohexital |
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| Synonyms |
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| Definitions |
A rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability, and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C66116 |
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| CAS_Registry |
151-83-7 18652-93-2 |
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| CHEBI_ID |
CHEBI:102216 |
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| Chemical_Formula |
C14H18N2O3 |
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| code |
C66116 |
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| Contributing_Source |
FDA |
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| definition |
A rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability, and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses. |
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| FDA_UNII_Code |
E5B8ND5IPE |
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| in_subset | ||
| label |
Methohexital |
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| Legacy Concept Name |
Methohexital |
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| Preferred_Name |
Methohexital |
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| prefixIRI |
NCIT:C66116 |
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| prefLabel |
Methohexital |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0025668 |
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| subClassOf |