loading...| Preferred Name |
Midazolam Hydrochloride |
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| Synonyms |
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|
| Definitions |
The hydrochloride salt of a short-acting benzodiazepine derivative with an imidazole structure and anxiolytic, amnestic, hypnotic, anticonvulsant and sedative properties. Midazolam binds to the benzodiazepine receptor at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS), resulting in increases in the opening of chloride channels, membrane hyperpolarization, and the inhibitory effect of GABA. This agent may also interfere with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C654 |
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| ALT_DEFINITION |
A drug used to treat anxiety and tension and to relax muscles. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of benzodiazepine. |
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| CAS_Registry |
59467-96-8 |
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| Chemical_Formula |
C18H13ClFN3.HCl |
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| code |
C654 |
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| Contributing_Source |
CPTAC CTRP FDA |
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| definition |
The hydrochloride salt of a short-acting benzodiazepine derivative with an imidazole structure and anxiolytic, amnestic, hypnotic, anticonvulsant and sedative properties. Midazolam binds to the benzodiazepine receptor at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS), resulting in increases in the opening of chloride channels, membrane hyperpolarization, and the inhibitory effect of GABA. This agent may also interfere with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft. |
|
| Display_Name |
Midazolam Hydrochloride |
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| FDA_UNII_Code |
W7TTW573JJ |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C156952 http://purl.obolibrary.org/obo/NCIT_C156953 http://purl.obolibrary.org/obo/NCIT_C116977 |
|
| label |
Midazolam Hydrochloride |
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| Legacy Concept Name |
Midazolam |
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| NCI_Drug_Dictionary_ID |
41056 |
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| PDQ_Closed_Trial_Search_ID |
41056 |
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| PDQ_Open_Trial_Search_ID |
41056 |
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| Preferred_Name |
Midazolam Hydrochloride |
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| prefixIRI |
NCIT:C654 |
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| prefLabel |
Midazolam Hydrochloride |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0042553 |
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| subClassOf |