loading...| Preferred Name |
Colistimethate Sodium |
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| Synonyms |
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| Definitions |
The sodium salt of colistimethate, a broad-spectrum polymyxin antibiotic against most aerobic Gram-negative bacteria except Proteus bacteria. Colistimethate sodium contains the pentasodium salt of the penta(methanesulfonic acid) derivative of colistin A as the major component and a small proportion of the petasodium salt of the pentamethanesulfonate derivative of colistin B. Colistins are cyclic polypeptides produced from Bacillus colistinus or B. polymyxa and function as a surfactant which penetrates into and disrupts the bacterial cell membrane, thereby resulting in bactericidal effect. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C65349 |
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| CAS_Registry |
8068-28-8 |
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| CHEBI_ID |
CHEBI:34650 |
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| code |
C65349 |
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| Contributing_Source |
FDA |
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| definition |
The sodium salt of colistimethate, a broad-spectrum polymyxin antibiotic against most aerobic Gram-negative bacteria except Proteus bacteria. Colistimethate sodium contains the pentasodium salt of the penta(methanesulfonic acid) derivative of colistin A as the major component and a small proportion of the petasodium salt of the pentamethanesulfonate derivative of colistin B. Colistins are cyclic polypeptides produced from Bacillus colistinus or B. polymyxa and function as a surfactant which penetrates into and disrupts the bacterial cell membrane, thereby resulting in bactericidal effect. |
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| FDA_UNII_Code |
XW0E5YS77G |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Colistimethate Sodium |
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| Legacy Concept Name |
Colistimethate_Sodium |
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| NCI_Drug_Dictionary_ID |
788862 |
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| PDQ_Closed_Trial_Search_ID |
788862 |
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| PDQ_Open_Trial_Search_ID |
788862 |
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| Preferred_Name |
Colistimethate Sodium |
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| prefixIRI |
NCIT:C65349 |
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| prefLabel |
Colistimethate Sodium |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0110462 |
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| subClassOf |