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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Cilastatin Sodium | |
| Synonyms |
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| Definitions |
The sodium salt form of cilastatin, a renal dehydropeptidase inhibitor, that can be used to inhibit the activity of renal dehydropeptidase. Upon administration of cilastatin sodium, cilastatin targets, binds to and inhibits the activity of renal dehydropeptidase. This reduces the breakdown of drugs, such as the broad spectrum beta-lactam carbapenem imipenem, by renal dehydropeptidase, and thereby increases the activity and therapeutic effect of such drugs that would otherwise be metabolized by renal dehydropeptidase. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C65329 |
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| CAS_Registry |
81129-83-1
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| CHEBI_ID |
CHEBI:59511
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| Chemical_Formula |
C16H24N2O5S.Na
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|
| code |
C65329
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|
| Contributing_Source |
FDA
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|
| definition |
The sodium salt form of cilastatin, a renal dehydropeptidase inhibitor, that can be used to inhibit the activity of renal dehydropeptidase. Upon administration of cilastatin sodium, cilastatin targets, binds to and inhibits the activity of renal dehydropeptidase. This reduces the breakdown of drugs, such as the broad spectrum beta-lactam carbapenem imipenem, by renal dehydropeptidase, and thereby increases the activity and therapeutic effect of such drugs that would otherwise be metabolized by renal dehydropeptidase.
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| FDA_UNII_Code |
5428WXZ74M
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Cilastatin Sodium
|
|
| Legacy Concept Name |
Cilastatin_Sodium
|
|
| NCI_Drug_Dictionary_ID |
806129
|
|
| Preferred_Name |
Cilastatin Sodium
|
|
| prefixIRI |
NCIT:C65329
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|
| prefLabel |
Cilastatin Sodium
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0282395
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| subClassOf |
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