Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Cefepime
Synonyms
Definitions

A semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefepime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
ID

http://purl.obolibrary.org/obo/NCIT_C65294
ALT_DEFINITION

A drug used to treat infection. It belongs to the family of drugs called cephalosporin antibiotics.
CAS_Registry

88040-23-7
CHEBI_ID

CHEBI:478164
Chemical_Formula

C19H24N6O5S2
code

C65294
Contributing_Source

FDA
definition

A semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefepime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
FDA_UNII_Code

807PW4VQE3
Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C1041
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Cefepime
Legacy Concept Name

Cefepime_Base
Preferred_Name

Cefepime
prefixIRI

NCIT:C65294
prefLabel

Cefepime
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0055003
subClassOf

http://purl.obolibrary.org/obo/NCIT_C357
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Mapping To Ontology Source
http://purl.obolibrary.org/obo/ARO_0000059 ARO LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 DRON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C043266 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026052 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/ATC/J01DE01 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022054 NDFRT LOOM
http://purl.jp/bio/4/id/200906020386526823 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96048006 SNOMEDCT LOOM
https://go.drugbank.com/drugs/DB01413 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/20481 RXNORM LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Cefepime SEPON LOOM
http://purl.bioontology.org/ontology/LNC/LP17165-9 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008443 LOINC LOOM
http://stirdf.jst.go.jp/id/200907005601174857 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-53590 SNMI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0055003 OCHV LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65294 NCIT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000022054 ODAE LOOM
http://purl.bioontology.org/ontology/VANDF/4024049 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/004974 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/D000077723 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13699 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 ODNAE LOOM