Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Vancomycin Hydrochloride
Synonyms
Definitions

The hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis. Vancomycin may also alter the permeability of bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis.
ID

http://purl.obolibrary.org/obo/NCIT_C65207
CAS_Registry

1404-93-9
Chemical_Formula

C66H75Cl2N9O24.ClH
code

C65207
Contributing_Source

FDA
definition

The hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis. Vancomycin may also alter the permeability of bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis.
FDA_UNII_Code

71WO621TJD
Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C925
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Vancomycin Hydrochloride
Legacy Concept Name

Vancomycin_Hydrochloride
Preferred_Name

Vancomycin Hydrochloride
prefixIRI

NCIT:C65207
prefLabel

Vancomycin Hydrochloride
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0205992
subClassOf

http://purl.obolibrary.org/obo/NCIT_C61101
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