Preferred Name |
Methoxsalen |
|
Synonyms |
|
|
Definitions |
A naturally occurring substance isolated from the seeds of the plant Ammi majus with photoactivating properties. As a member of the family of compounds known as psoralens or furocoumarins, methoxsalen's exact mechanism of action is unknown; upon photoactivation, methoxsalen has been observed to bind covalently to and crosslink DNA. (NCI04) |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C643 |
|
Accepted_Therapeutic_Use_For |
Cutaneous T-cell lymphoma; psoriasis; vitiligo |
|
ALT_DEFINITION |
A drug used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. It is also being studied in the treatment of graft-versus-host disease. It belongs to the family of drugs called psoralens and furocoumarins. |
|
CAS_Registry |
298-81-7 |
|
CHEBI_ID |
CHEBI:18358 |
|
Chemical_Formula |
C12H8O4 |
|
code |
C643 |
|
Contributing_Source |
CTRP FDA |
|
definition |
A naturally occurring substance isolated from the seeds of the plant Ammi majus with photoactivating properties. As a member of the family of compounds known as psoralens or furocoumarins, methoxsalen's exact mechanism of action is unknown; upon photoactivation, methoxsalen has been observed to bind covalently to and crosslink DNA. (NCI04) |
|
Display_Name |
Methoxsalen |
|
FDA_UNII_Code |
U4VJ29L7BQ |
|
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
Is_Value_For_GDC_Property | ||
label |
Methoxsalen |
|
Legacy Concept Name |
Methoxsalen |
|
Maps_To |
Methoxsalen |
|
NCI_Drug_Dictionary_ID |
39499 |
|
NSC Number |
45923 |
|
PDQ_Closed_Trial_Search_ID |
39499 |
|
PDQ_Open_Trial_Search_ID |
39499 |
|
Preferred_Name |
Methoxsalen |
|
prefixIRI |
NCIT:C643 |
|
prefLabel |
Methoxsalen |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0025684 |
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subClassOf |