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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Medroxyprogesterone | |
| Synonyms |
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| Definitions |
A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C629 |
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| Accepted_Therapeutic_Use_For |
Breast carcinoma; Contraception; Endometrial carcinoma; Renal cell carcinoma
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| ALT_DEFINITION |
A hormonal anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called progestins.
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| CAS_Registry |
520-85-4
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| CHEBI_ID |
CHEBI:6715
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| Chemical_Formula |
C22H32O3
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| code |
C629
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| Contributing_Source |
CTRP FDA
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|
| definition |
A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. (NCI04)
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| Display_Name |
Medroxyprogesterone
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|
| FDA_UNII_Code |
HSU1C9YRES
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Medroxyprogesterone
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|
| Legacy Concept Name |
Medroxyprogesterone
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|
| Maps_To |
Medroxyprogesterone
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| NCI_Drug_Dictionary_ID |
39813
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| NSC Number |
27408
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| PDQ_Closed_Trial_Search_ID |
39813
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| PDQ_Open_Trial_Search_ID |
39813
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| Preferred_Name |
Medroxyprogesterone
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|
| prefixIRI |
NCIT:C629
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|
| prefLabel |
Medroxyprogesterone
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0025147
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| subClassOf |
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