loading...| Preferred Name |
Mechlorethamine Hydrochloride |
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| Synonyms |
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| Definitions |
The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C627 |
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| Accepted_Therapeutic_Use_For |
Bronchogenic carcinoma; chronic lymphocytic and myelcytic leukemia; Hodgkins dieseas, palliative; lymphosarcoma; mycosis fungoides; polycythemia vera |
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| ALT_DEFINITION |
A drug used to treat some types of cancer and some skin conditions that may become cancer. It attaches to the cell's DNA and may kill cancer cells. Mechlorethamine hydrochloride is a type of alkylating agent. |
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| CAS_Registry |
55-86-7 |
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| CHEBI_ID |
CHEBI:55368 |
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| Chemical_Formula |
C5H11Cl2N.HCl |
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| code |
C627 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. |
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| Display_Name |
Mechlorethamine Hydrochloride |
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| FDA_UNII_Code |
L0MR697HHI |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Mechlorethamine Hydrochloride |
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| Legacy Concept Name |
Nitrogen_Mustard |
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| Maps_To |
Mechlorethamine Hydrochloride |
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| NCI_Drug_Dictionary_ID |
43434 |
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| NSC Number |
762 |
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| PDQ_Closed_Trial_Search_ID |
43434 |
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| PDQ_Open_Trial_Search_ID |
43434 |
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| Preferred_Name |
Mechlorethamine Hydrochloride |
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| prefixIRI |
NCIT:C627 |
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| prefLabel |
Mechlorethamine Hydrochloride |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0600266 |
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| subClassOf |