loading...| Preferred Name | Tamoxifen | |
| Synonyms |
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| Definitions |
An antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C62078 |
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| ALT_DEFINITION |
A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen. |
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| CAS_Registry |
10540-29-1 |
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| CHEBI_ID |
CHEBI:41774 |
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| Chemical_Formula |
C26H29NO |
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| code |
C62078 |
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| Contributing_Source |
CTRP FDA |
|
| definition |
An antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. |
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| Display_Name |
Tamoxifen |
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| FDA_UNII_Code |
094ZI81Y45 |
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| Has_Salt_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Tamoxifen |
|
| Legacy Concept Name |
Tamoxifen_Base |
|
| Maps_To |
Tamoxifen |
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| Preferred_Name |
Tamoxifen |
|
| prefixIRI |
NCIT:C62078 |
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| prefLabel |
Tamoxifen |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0039286 |
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| subClassOf |