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Biological and Environmental Research Ontology
| Preferred Name | Procarbazine | |
| Synonyms |
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| Definitions |
A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C62072 |
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| ALT_DEFINITION |
The active ingredient in a drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Procarbazine blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent.
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| CAS_Registry |
671-16-9
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| Chemical_Formula |
C12H19N3O
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| code |
C62072
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| Contributing_Source |
CTRP FDA PCDC
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| definition |
A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
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| Display_Name |
Procarbazine
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| FDA_UNII_Code |
35S93Y190K
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 |
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| Is_Value_For_GDC_Property | ||
| label |
Procarbazine
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| Legacy Concept Name |
Procarbazine_Base
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| Maps_To |
Procarbazine
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| Preferred_Name |
Procarbazine
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| prefixIRI |
NCIT:C62072
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| prefLabel |
Procarbazine
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0033223
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| subClassOf |
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