Preferred Name |
Phentolamine |
|
Synonyms |
|
|
Definitions |
A synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C62066 |
|
CAS_Registry |
50-60-2 |
|
Chemical_Formula |
C17H19N3O |
|
code |
C62066 |
|
Contributing_Source |
FDA |
|
definition |
A synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. |
|
FDA_UNII_Code |
Z468598HBV |
|
Has_Salt_Form | ||
in_subset | ||
label |
Phentolamine |
|
Legacy Concept Name |
Phentolamine_Base |
|
Preferred_Name |
Phentolamine |
|
prefixIRI |
NCIT:C62066 |
|
prefLabel |
Phentolamine |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0031448 |
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subClassOf |