loading...| Preferred Name |
Phenoxybenzamine |
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| Synonyms |
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| Definitions |
A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C62065 |
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| CAS_Registry |
59-96-1 |
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| Chemical_Formula |
C18H22ClNO |
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| code |
C62065 |
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| Contributing_Source |
FDA |
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| definition |
A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. |
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| FDA_UNII_Code |
0TTZ664R7Z |
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Phenoxybenzamine |
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| Legacy Concept Name |
Phenoxybenzamine_Base |
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| Preferred_Name |
Phenoxybenzamine |
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| prefixIRI |
NCIT:C62065 |
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| prefLabel |
Phenoxybenzamine |
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| Semantic_Type |
Pharmacologic Substance Hazardous or Poisonous Substance |
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| UMLS_CUI |
C0031441 |
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| subClassOf |