loading...| Preferred Name |
Mechlorethamine |
|
| Synonyms |
|
|
| Definitions |
A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C62056 |
|
| ALT_DEFINITION |
The nitrogen mustard vesicant HN-2. |
|
| CAS_Registry |
51-75-2 |
|
| CHEBI_ID |
CHEBI:28925 |
|
| Chemical_Formula |
C5H11Cl2N |
|
| code |
C62056 |
|
| Contributing_Source |
CDISC FDA PCDC |
|
| definition |
A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04) |
|
| FDA_UNII_Code |
50D9XSG0VR |
|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C77526 http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C160930 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 http://purl.obolibrary.org/obo/NCIT_C157711 |
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| Is_Value_For_GDC_Property | ||
| label |
Mechlorethamine |
|
| Legacy Concept Name |
Mechlorethamine |
|
| Maps_To |
Mechlorethamine |
|
| Preferred_Name |
Mechlorethamine |
|
| prefixIRI |
NCIT:C62056 |
|
| prefLabel |
Mechlorethamine |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0025033 |
|
| subClassOf |