loading...| Preferred Name |
Trientine Hydrochloride |
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| Synonyms |
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| Definitions |
The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8). |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61987 |
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| CAS_Registry |
38260-01-4 |
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| Chemical_Formula |
C6H18N4.2HCl |
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| code |
C61987 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8). |
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| Display_Name |
Trientine Hydrochloride |
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| FDA_UNII_Code |
HC3NX54582 |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Trientine Hydrochloride |
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| Legacy Concept Name |
Trientine_Hydrochloride |
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| Maps_To |
Trientine Hydrochloride |
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| NCI_Drug_Dictionary_ID |
683662 |
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| PDQ_Closed_Trial_Search_ID |
683662 |
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| PDQ_Open_Trial_Search_ID |
683662 |
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| Preferred_Name |
Trientine Hydrochloride |
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| prefixIRI |
NCIT:C61987 |
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| prefLabel |
Trientine Hydrochloride |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0770325 |
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| subClassOf |