loading...| Preferred Name |
Sorafenib |
|
| Synonyms |
|
|
| Definitions |
A synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C61948 |
|
| ALT_DEFINITION |
A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Sorafenib stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent. |
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| CAS_Registry |
284461-73-0 |
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| CHEBI_ID |
CHEBI:50924 |
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| Chemical_Formula |
C21H16ClF3N4O3 |
|
| code |
C61948 |
|
| Contributing_Source |
CTRP FDA PCDC |
|
| definition |
A synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. |
|
| Display_Name |
Sorafenib |
|
| FDA_UNII_Code |
9ZOQ3TZI87 |
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| Has_Salt_Form | ||
| Has_Target |
http://purl.obolibrary.org/obo/NCIT_C17476 http://purl.obolibrary.org/obo/NCIT_C17484 http://purl.obolibrary.org/obo/NCIT_C26203 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C174019 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 |
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| Is_PCDC_AML_Permissible_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Sorafenib |
|
| Legacy Concept Name |
Sorafenib |
|
| Maps_To |
Sorafenib |
|
| Preferred_Name |
Sorafenib |
|
| prefixIRI |
NCIT:C61948 |
|
| prefLabel |
Sorafenib |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1516119 |
|
| subClassOf |
http://purl.obolibrary.org/obo/NCIT_C93259 http://purl.obolibrary.org/obo/NCIT_C159199 |