Preferred Name

Piperazine

Synonyms
Definitions

A cyclic organic compound possessing two nitrogen atoms in opposite positions within a 6-member heterocyclic ring that serves as a backbone for piperazine derivatives and acts as a gamma-amino-butyric acid (GABA) receptor agonist in nematodes, with potential anti-helminthic activity. Upon administration, piperazine binds to the GABA inhibitory receptors in susceptible nematodes, thereby inducing chloride channel opening and hyperpolarization. This results in paralysis of the worm musculature and allows normal peristalsis to dislodge the worm from the intestinal lumen, which causes the worm to be expelled from the body. Unlike vertebrates where GABA is restricted to the central nervous system (CNS), the GABA receptors in helminths are also expressed in the peripheral nervous system.

ID

http://purl.obolibrary.org/obo/NCIT_C61892

CAS_Registry

110-85-0

CHEBI_ID

CHEBI:28568

Chemical_Formula

C4H10N2

code

C61892

Contributing_Source

FDA

definition

A cyclic organic compound possessing two nitrogen atoms in opposite positions within a 6-member heterocyclic ring that serves as a backbone for piperazine derivatives and acts as a gamma-amino-butyric acid (GABA) receptor agonist in nematodes, with potential anti-helminthic activity. Upon administration, piperazine binds to the GABA inhibitory receptors in susceptible nematodes, thereby inducing chloride channel opening and hyperpolarization. This results in paralysis of the worm musculature and allows normal peristalsis to dislodge the worm from the intestinal lumen, which causes the worm to be expelled from the body. Unlike vertebrates where GABA is restricted to the central nervous system (CNS), the GABA receptors in helminths are also expressed in the peripheral nervous system.

FDA_UNII_Code

1RTM4PAL0V

Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C47674

http://purl.obolibrary.org/obo/NCIT_C76724

http://purl.obolibrary.org/obo/NCIT_C75970

http://purl.obolibrary.org/obo/NCIT_C81514

http://purl.obolibrary.org/obo/NCIT_C80008

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

label

Piperazine

Legacy Concept Name

Piperazine

Preferred_Name

Piperazine

prefixIRI

NCIT:C61892

prefLabel

Piperazine

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0031957

subClassOf

http://purl.obolibrary.org/obo/NCIT_C250

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_28568 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28568 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_28568 CHEBI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0031957 OCHV LOOM
http://www.drugbank.ca/drugs/DB00592 FTC LOOM
http://purl.jp/bio/4/id/200906098212553740 IOBC LOOM
https://go.drugbank.com/drugs/DB00592 MDM LOOM
http://purl.bioontology.org/ontology/RCD/eq2.. RCD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/428714003 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61892 NCIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9746 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147982 NDFRT LOOM
http://purl.bioontology.org/ontology/CSP/2332-0723 CRISP LOOM
http://www.co-ode.org/ontologies/galen#Piperazine GALEN LOOM
http://purl.obolibrary.org/obo/dinto_DB00592 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_26144 GSSO LOOM
http://purl.bioontology.org/ontology/VANDF/4019897 VANDF LOOM
http://purl.bioontology.org/ontology/MESH/D000077489 MESH LOOM
http://purl.bioontology.org/ontology/ATC/P02CB01 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/8340 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907089013174548 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_28568 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_28568 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28568 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_28568 NIFSTD LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026666 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C034930 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002977 NDDF LOOM