loading...| Preferred Name |
Midodrine |
|
| Synonyms |
|
|
| Definitions |
A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS). |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C61846 |
|
| CAS_Registry |
42794-76-3 |
|
| CHEBI_ID |
CHEBI:6933 |
|
| Chemical_Formula |
C12H18N2O4 |
|
| code |
C61846 |
|
| Contributing_Source |
FDA |
|
| definition |
A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS). |
|
| FDA_UNII_Code |
6YE7PBM15H |
|
| Has_Salt_Form | ||
| in_subset | ||
| label |
Midodrine |
|
| Legacy Concept Name |
Midodrine |
|
| Preferred_Name |
Midodrine |
|
| prefixIRI |
NCIT:C61846 |
|
| prefLabel |
Midodrine |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0026078 |
|
| subClassOf |