loading...| Preferred Name |
Mefloquine |
|
| Synonyms |
|
|
| Definitions |
A quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death. Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C61827 |
|
| CAS_Registry |
53230-10-7 |
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| CHEBI_ID |
CHEBI:63609 |
|
| Chemical_Formula |
C17H16F6N2O |
|
| code |
C61827 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death. Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration. |
|
| Display_Name |
Mefloquine |
|
| FDA_UNII_Code |
TML814419R |
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Mefloquine |
|
| Legacy Concept Name |
Mefloquine |
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| NCI_Drug_Dictionary_ID |
711805 |
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| PDQ_Closed_Trial_Search_ID |
711805 |
|
| PDQ_Open_Trial_Search_ID |
711805 |
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| Preferred_Name |
Mefloquine |
|
| prefixIRI |
NCIT:C61827 |
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| prefLabel |
Mefloquine |
|
| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0025153 |
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| subClassOf |