Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Gemifloxacin
Synonyms
Definitions

A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway before targeting both DNA gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair. This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the enzyme thereby preventing the bacterial chromosome from rejoining. This interferes with DNA replication and repair processes as well as transcription, and ultimately leads to bacterial cell death. Gemifloxacin targets at both Gram-positive, -negative and atypical human pathogens.
ID

http://purl.obolibrary.org/obo/NCIT_C61775
CAS_Registry

175463-14-6

204519-64-2
CHEBI_ID

CHEBI:101853
Chemical_Formula

C18H20FN5O4
code

C61775
Contributing_Source

FDA
definition

A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway before targeting both DNA gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair. This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the enzyme thereby preventing the bacterial chromosome from rejoining. This interferes with DNA replication and repair processes as well as transcription, and ultimately leads to bacterial cell death. Gemifloxacin targets at both Gram-positive, -negative and atypical human pathogens.
FDA_UNII_Code

OKR68Y0E4T
Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C47548
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Gemifloxacin
Legacy Concept Name

Gemifloxacin
Preferred_Name

Gemifloxacin
prefixIRI

NCIT:C61775
prefLabel

Gemifloxacin
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0533545
subClassOf

http://purl.obolibrary.org/obo/NCIT_C795
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