loading...| Preferred Name |
Epiandrosterone |
|
| Synonyms |
|
|
| Definitions |
A dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property. Epiandrosterone, a potential neurosteroid, appears to bind to the gamma-aminobutyric acid (GABA)/benzodiazepine-receptor complex (GABA-RC), acting as a negative non-competitive modulator of GABA-RC as well as signal through the N-methyl-D-aspartate receptor. In addition this agent inhibits the pentose phosphate pathway (PPP) thereby dilating blood vessels pre-contracted by partial depolarization. Also, epiandrosterone inhibits the synthesis of thromboxane A2 in activated platelets, reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen, increases serum levels of insulin-like growth factor 1 and increases cyclic guanosine monophosphate and nitric oxide synthesis. These effects may improve circulation in the microvasculature. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61747 |
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| CAS_Registry |
481-29-8 |
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| CHEBI_ID |
CHEBI:541975 |
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| Chemical_Formula |
C19H30O2 |
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| code |
C61747 |
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| Contributing_Source |
FDA |
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| definition |
A dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property. Epiandrosterone, a potential neurosteroid, appears to bind to the gamma-aminobutyric acid (GABA)/benzodiazepine-receptor complex (GABA-RC), acting as a negative non-competitive modulator of GABA-RC as well as signal through the N-methyl-D-aspartate receptor. In addition this agent inhibits the pentose phosphate pathway (PPP) thereby dilating blood vessels pre-contracted by partial depolarization. Also, epiandrosterone inhibits the synthesis of thromboxane A2 in activated platelets, reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen, increases serum levels of insulin-like growth factor 1 and increases cyclic guanosine monophosphate and nitric oxide synthesis. These effects may improve circulation in the microvasculature. |
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| FDA_UNII_Code |
8TR252Z538 |
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| in_subset | ||
| label |
Epiandrosterone |
|
| Legacy Concept Name |
Epiandrosterone |
|
| Preferred_Name |
Epiandrosterone |
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| prefixIRI |
NCIT:C61747 |
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| prefLabel |
Epiandrosterone |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0014483 |
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| subClassOf |