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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Diphenhydramine | |
| Synonyms |
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| Definitions |
A first generation antihistamine and ethanolamine with sedative and anti-allergic properties. Diphenhydramine competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61728 |
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| ALT_DEFINITION |
A drug used to treat allergies and relieve cough and itching caused by insect bites, sunburn, and poison oak or ivy. It is also used to treat mild Parkinson disease, to prevent and treat motion sickness, to relieve cough and cold symptoms, and as a sleep aid. It is a type of antihistamine.
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| CAS_Registry |
58-73-1
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| CHEBI_ID |
CHEBI:4636
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| Chemical_Formula |
C17H21NO
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| code |
C61728
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| Contributing_Source |
CTRP FDA
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|
| definition |
A first generation antihistamine and ethanolamine with sedative and anti-allergic properties. Diphenhydramine competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.
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| Display_Name |
Diphenhydramine
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|
| FDA_UNII_Code |
8GTS82S83M
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|
| Has_Salt_Form |
http://purl.obolibrary.org/obo/NCIT_C82274 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Diphenhydramine
|
|
| Legacy Concept Name |
Diphenhydramine
|
|
| Preferred_Name |
Diphenhydramine
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|
| prefixIRI |
NCIT:C61728
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| prefLabel |
Diphenhydramine
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0012522
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| subClassOf |
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