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Biological and Environmental Research Ontology
| Preferred Name | Limonene, (+/-)- | |
| Synonyms |
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|
| Definitions |
A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61709 |
|
| CAS_Registry |
138-86-3
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|
| CHEBI_ID |
CHEBI:15384
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| Chemical_Formula |
C10H16
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|
| code |
C61709
|
|
| Contributing_Source |
FDA
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|
| definition |
A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes.
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| FDA_UNII_Code |
9MC3I34447
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Limonene, (+/-)-
|
|
| Legacy Concept Name |
DL-Limonene
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|
| Maps_To |
Limonene, (+/-)-
|
|
| NSC Number |
21446 844
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|
| Preferred_Name |
Limonene, (+/-)-
|
|
| prefixIRI |
NCIT:C61709
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|
| prefLabel |
Limonene, (+/-)-
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C1880232
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| subClassOf |
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