Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Carboprost
Synonyms
Definitions

The (15S)-15 methyl analogue of naturally occurring prostaglandin F2 alpha (PGF2 alpha) with oxytocic activity. Mimicking endogenous PGF2 alpha, carboprost activates prostaglandin F receptor, a G-protein coupled receptor, on smooth muscle cells, thereby resulting in smooth muscle contractions. When administered intramuscularly on gravid subjects, this agent induces myometrium contractions, thereby initiating luteolysis and consequently parturition. Furthermore, carboprost's action on vascular smooth muscle and gastrointestinal tract sphincters leads to raised blood pressure and induces vomiting or diarrhea, respectively.
ID

http://purl.obolibrary.org/obo/NCIT_C61662
CAS_Registry

35700-23-3
CHEBI_ID

CHEBI:3403
Chemical_Formula

C21H36O5
code

C61662
Contributing_Source

FDA
definition

The (15S)-15 methyl analogue of naturally occurring prostaglandin F2 alpha (PGF2 alpha) with oxytocic activity. Mimicking endogenous PGF2 alpha, carboprost activates prostaglandin F receptor, a G-protein coupled receptor, on smooth muscle cells, thereby resulting in smooth muscle contractions. When administered intramuscularly on gravid subjects, this agent induces myometrium contractions, thereby initiating luteolysis and consequently parturition. Furthermore, carboprost's action on vascular smooth muscle and gastrointestinal tract sphincters leads to raised blood pressure and induces vomiting or diarrhea, respectively.
FDA_UNII_Code

7B5032XT6O
Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C47433
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Carboprost
Legacy Concept Name

Carboprost
Preferred_Name

Carboprost
prefixIRI

NCIT:C61662
prefLabel

Carboprost
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0007047
subClassOf

http://purl.obolibrary.org/obo/NCIT_C78568
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