Preferred Name

Almotriptan Malate
Synonyms
Definitions

The malate salt of almotriptan, a sulfonamide triptan with vasoconstrictor activity. Almotriptan selectively binds to and activates serotonin 5-HT 1B and 1D receptors in the central nervous system (CNS), thereby causing cerebral blood vessel constriction. This may lead to pain relief from vascular headaches. Almotriptan may also relieve vascular headaches by preventing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.

ID

http://purl.obolibrary.org/obo/NCIT_C61628

CAS_Registry

181183-52-8

CHEBI_ID

CHEBI:53781

Chemical_Formula

C17H25N3O2S.C4H6O5

code

C61628

Contributing_Source

FDA

definition

The malate salt of almotriptan, a sulfonamide triptan with vasoconstrictor activity. Almotriptan selectively binds to and activates serotonin 5-HT 1B and 1D receptors in the central nervous system (CNS), thereby causing cerebral blood vessel constriction. This may lead to pain relief from vascular headaches. Almotriptan may also relieve vascular headaches by preventing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.

FDA_UNII_Code

PJP312605E

Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C65224

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

label

Almotriptan Malate

Legacy Concept Name

Almotriptan_Malate

Preferred_Name

Almotriptan Malate

prefixIRI

NCIT:C61628

prefLabel

Almotriptan Malate

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0937898

subClassOf

http://purl.obolibrary.org/obo/NCIT_C47794

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