loading...| Preferred Name |
Pazopanib Hydrochloride |
|
| Synonyms |
|
|
| Definitions |
The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C60779 |
|
| ALT_DEFINITION |
A drug that is used to treat kidney cancer and is being studied in the treatment of other types of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of protein tyrosine kinase inhibitor and a type of antiangiogenesis agent. |
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| CAS_Registry |
635702-64-6 |
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| Chemical_Formula |
C21H23N7O2S.HCl |
|
| code |
C60779 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. |
|
| Display_Name |
Pazopanib Hydrochloride |
|
| FDA_UNII_Code |
33Y9ANM545 |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target |
http://purl.obolibrary.org/obo/NCIT_C17328 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Pazopanib Hydrochloride |
|
| Legacy Concept Name |
Pazopanib |
|
| Maps_To |
Pazopanib Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
476479 |
|
| NSC Number |
737754 |
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| PDQ_Closed_Trial_Search_ID |
476479 |
|
| PDQ_Open_Trial_Search_ID |
476479 |
|
| Preferred_Name |
Pazopanib Hydrochloride |
|
| prefixIRI |
NCIT:C60779 |
|
| prefLabel |
Pazopanib Hydrochloride |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1872226 |
|
| subClassOf |
http://purl.obolibrary.org/obo/NCIT_C93259 http://purl.obolibrary.org/obo/NCIT_C155727 |