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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Isosorbide | |
| Synonyms |
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| Definitions |
An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C60773 |
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| CAS_Registry |
652-67-5
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| Chemical_Formula |
C6H10O4
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| code |
C60773
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| Contributing_Source |
FDA
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|
| definition |
An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area.
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| FDA_UNII_Code |
WXR179L51S
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| Has_Salt_Form | ||
| Has_Target | ||
| in_subset | ||
| label |
Isosorbide
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|
| Legacy Concept Name |
Isosorbide
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| NSC Number |
40725
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| Preferred_Name |
Isosorbide
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| prefixIRI |
NCIT:C60773
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| prefLabel |
Isosorbide
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0022251
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| subClassOf |
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