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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Ketoconazole | |
| Synonyms |
|
|
| Definitions |
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C605 |
|
| Accepted_Therapeutic_Use_For |
Seborrheic Dermatitis; Prostate cancer
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|
| ALT_DEFINITION |
A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.
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| CAS_Registry |
65277-42-1
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|
| CHEBI_ID |
CHEBI:47519
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|
| Chemical_Formula |
C26H28Cl2N4O4
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|
| code |
C605
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|
| Contributing_Source |
CTRP FDA
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|
| definition |
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)
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|
| Display_Name |
Ketoconazole
|
|
| FDA_UNII_Code |
R9400W927I
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Ketoconazole
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|
| Legacy Concept Name |
Ketoconazole
|
|
| Maps_To |
Ketoconazole
|
|
| NCI_Drug_Dictionary_ID |
39488
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|
| NSC Number |
317629
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|
| PDQ_Closed_Trial_Search_ID |
39488
|
|
| PDQ_Open_Trial_Search_ID |
39488
|
|
| Preferred_Name |
Ketoconazole
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|
| prefixIRI |
NCIT:C605
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|
| prefLabel |
Ketoconazole
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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|
| UMLS_CUI |
C0022625
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|
| subClassOf |
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