loading...| Preferred Name |
Recombinant Interferon Gamma |
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| Synonyms |
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|
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C583 |
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| Accepted_Therapeutic_Use_For |
Chronic granulomatous disease; Osteopetrosis |
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| CAS_Registry |
82115-62-6 |
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| code |
C583 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04) |
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| Display_Name |
Recombinant Interferon Gamma |
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| FDA_UNII_Code |
P050J5FWC5 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Recombinant Interferon Gamma |
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| Legacy Concept Name |
Therapeutic_Interferon_Gamma |
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| Maps_To |
Recombinant Interferon Gamma |
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| NCI_Drug_Dictionary_ID |
40469 |
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| NSC Number |
600662 635256 |
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| PDQ_Closed_Trial_Search_ID |
40469 |
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| PDQ_Open_Trial_Search_ID |
40469 |
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| Preferred_Name |
Recombinant Interferon Gamma |
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| prefixIRI |
NCIT:C583 |
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| prefLabel |
Recombinant Interferon Gamma |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C3539881 |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/PDQ/CDR0000040469 | PDQ | LOOM | |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C583 | NCIT | LOOM |