Link to this page
Biological and Environmental Research Ontology
| Preferred Name | Recombinant Interferon Gamma | |
| Synonyms |
|
|
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C583 |
|
| Accepted_Therapeutic_Use_For |
Chronic granulomatous disease; Osteopetrosis
|
|
| CAS_Registry |
82115-62-6
|
|
| code |
C583
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)
|
|
| Display_Name |
Recombinant Interferon Gamma
|
|
| FDA_UNII_Code |
P050J5FWC5
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Recombinant Interferon Gamma
|
|
| Legacy Concept Name |
Therapeutic_Interferon_Gamma
|
|
| Maps_To |
Recombinant Interferon Gamma
|
|
| NCI_Drug_Dictionary_ID |
40469
|
|
| NSC Number |
600662 635256
|
|
| PDQ_Closed_Trial_Search_ID |
40469
|
|
| PDQ_Open_Trial_Search_ID |
40469
|
|
| Preferred_Name |
Recombinant Interferon Gamma
|
|
| prefixIRI |
NCIT:C583
|
|
| prefLabel |
Recombinant Interferon Gamma
|
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
|
|
| UMLS_CUI |
C3539881
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.bioontology.org/ontology/PDQ/CDR0000040469 | PDQ | LOOM |
| http://purl.bioontology.org/ontology/PDQ/CDR0000040469 | PDQ | LOOM |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C583 | NCIT | LOOM |