Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Recombinant Interferon
Synonyms
Definitions

One of a group of recombinant therapeutic glycoprotein cytokines with antiviral, anti-proliferative, and immunomodulating activities. Interferons bind to specific cell-surface receptors, leading to the transcription and translation of genes with interferon-specific response elements (ISREs). The resultant proteins mediate many complex effects, ultimately leading to inhibition of viral protein synthesis and cellular growth, alteration of cellular differentiation, interference with oncogene expression, activation of natural killer cells, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity. The production of endogenous interferons is induced in response to foreign agents such as bacteria, viruses and parasites and to tumor cells.
ID

http://purl.obolibrary.org/obo/NCIT_C584
CAS_Registry

9008-1-11
code

C584
definition

One of a group of recombinant therapeutic glycoprotein cytokines with antiviral, anti-proliferative, and immunomodulating activities. Interferons bind to specific cell-surface receptors, leading to the transcription and translation of genes with interferon-specific response elements (ISREs). The resultant proteins mediate many complex effects, ultimately leading to inhibition of viral protein synthesis and cellular growth, alteration of cellular differentiation, interference with oncogene expression, activation of natural killer cells, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity. The production of endogenous interferons is induced in response to foreign agents such as bacteria, viruses and parasites and to tumor cells.
in_subset

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909
label

Recombinant Interferon
Legacy Concept Name

Therapeutic_Interferon
Maps_To

Recombinant Interferon
NCI_Drug_Dictionary_ID

40863
NSC Number

339140
PDQ_Closed_Trial_Search_ID

40863
PDQ_Open_Trial_Search_ID

40863
Preferred_Name

Recombinant Interferon
prefixIRI

NCIT:C584
prefLabel

Recombinant Interferon
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
UMLS_CUI

C1522537
subClassOf

http://purl.obolibrary.org/obo/NCIT_C1283
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