loading...| Preferred Name |
Hydroxyurea |
|
| Synonyms |
|
|
| Definitions |
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C560 |
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| Accepted_Therapeutic_Use_For |
Chronic Myelogenous Leukemia; Head and Neck Cancer; Malignant Melanoma; Ovarian Carcinoma; Sickle Cell Anemia; Adjuvant in Retroviral Therapy. |
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called antimetabolites. |
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| CAS_Registry |
127-07-1 |
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| CHEBI_ID |
CHEBI:44423 |
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| Chemical_Formula |
CH4N2O2 |
|
| code |
C560 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04) |
|
| Display_Name |
Hydroxyurea |
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| FDA_UNII_Code |
X6Q56QN5QC |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Hydroxyurea |
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| Legacy Concept Name |
Hydroxyurea |
|
| Maps_To |
Hydroxyurea |
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| NCI_Drug_Dictionary_ID |
40685 |
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| NSC Number |
32065 |
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| PDQ_Closed_Trial_Search_ID |
40685 |
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| PDQ_Open_Trial_Search_ID |
40685 |
|
| Preferred_Name |
Hydroxyurea |
|
| prefixIRI |
NCIT:C560 |
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| prefLabel |
Hydroxyurea |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0020402 |
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| subClassOf |