Preferred Name

Cabozantinib
Synonyms
Definitions

An orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression.

ID

http://purl.obolibrary.org/obo/NCIT_C52200

CAS_Registry

849217-68-1

Chemical_Formula

C28H24FN3O5

code

C52200

Contributing_Source

CTRP

FDA

PCDC

definition

An orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression.

Display_Name

Cabozantinib

FDA_UNII_Code

1C39JW444G

Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C97938

Has_Target

http://purl.obolibrary.org/obo/NCIT_C26203

http://purl.obolibrary.org/obo/NCIT_C17475

http://purl.obolibrary.org/obo/NCIT_C18539

http://purl.obolibrary.org/obo/NCIT_C18488

http://purl.obolibrary.org/obo/NCIT_C17328

http://purl.obolibrary.org/obo/NCIT_C26202

http://purl.obolibrary.org/obo/NCIT_C18186

http://purl.obolibrary.org/obo/NCIT_C17975

http://purl.obolibrary.org/obo/NCIT_C28496

http://purl.obolibrary.org/obo/NCIT_C33983

in_subset

http://purl.obolibrary.org/obo/NCIT_C179531

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C179478

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712

Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909

label

Cabozantinib

Legacy Concept Name

XL184

Maps_To

Cabozantinib

Preferred_Name

Cabozantinib

prefixIRI

NCIT:C52200

prefLabel

Cabozantinib

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C3181682

subClassOf

http://purl.obolibrary.org/obo/NCIT_C93259

http://purl.obolibrary.org/obo/NCIT_C159438

http://purl.obolibrary.org/obo/NCIT_C143099

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