loading...| Preferred Name | Flutamide | |
| Synonyms |
|
|
| Definitions |
A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C509 |
|
| Accepted_Therapeutic_Use_For |
Hirsutism; Prostate carcinoma |
|
| ALT_DEFINITION |
An anticancer drug that is a type of antiandrogen. |
|
| CAS_Registry |
13311-84-7 |
|
| CHEBI_ID |
CHEBI:5132 |
|
| Chemical_Formula |
C11H11F3N2O3 |
|
| code |
C509 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04) |
|
| Display_Name |
Flutamide |
|
| FDA_UNII_Code |
76W6J0943E |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Flutamide |
|
| Legacy Concept Name |
Flutamide |
|
| Maps_To |
Flutamide |
|
| NCI_Drug_Dictionary_ID |
39811 |
|
| NSC Number |
147834 215876 |
|
| PDQ_Closed_Trial_Search_ID |
39811 |
|
| PDQ_Open_Trial_Search_ID |
39811 |
|
| Preferred_Name |
Flutamide |
|
| prefixIRI |
NCIT:C509 |
|
| prefLabel |
Flutamide |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0016384 |
|
| subClassOf |