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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Flucytosine | |
| Synonyms |
|
|
| Definitions |
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C501 |
|
| ALT_DEFINITION |
A drug that treats infections caused by fungi.
|
|
| CAS_Registry |
2022-85-7
|
|
| CHEBI_ID |
CHEBI:5100
|
|
| Chemical_Formula |
C4H4FN3O
|
|
| code |
C501
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.
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|
| Display_Name |
Flucytosine
|
|
| FDA_UNII_Code |
D83282DT06
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Flucytosine
|
|
| Legacy Concept Name |
Flucytosine
|
|
| NCI_Drug_Dictionary_ID |
41023
|
|
| NSC Number |
103805
|
|
| PDQ_Closed_Trial_Search_ID |
41023
|
|
| PDQ_Open_Trial_Search_ID |
41023
|
|
| Preferred_Name |
Flucytosine
|
|
| prefixIRI |
NCIT:C501
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|
| prefLabel |
Flucytosine
|
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
|
|
| UMLS_CUI |
C0016278
|
|
| subClassOf |
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