Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Recombinant Interferon Beta
Synonyms
Definitions

A recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. (NCI05)
ID

http://purl.obolibrary.org/obo/NCIT_C495
Accepted_Therapeutic_Use_For

multiple sclerosis
CAS_Registry

77238-31-4
code

C495
Contributing_Source

CTRP

FDA
definition

A recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. (NCI05)
Display_Name

Recombinant Interferon Beta
FDA_UNII_Code

V9GU1EM8SF
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C173383

http://purl.obolibrary.org/obo/NCIT_C173381

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712
Is_Related_To_Endogenous_Product

http://purl.obolibrary.org/obo/NCIT_C20495
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909
label

Recombinant Interferon Beta
Legacy Concept Name

Therapeutic_Interferon_Beta
Maps_To

Recombinant Interferon Beta
NCI_Drug_Dictionary_ID

40468
NSC Number

373361

658933
PDQ_Closed_Trial_Search_ID

40468
PDQ_Open_Trial_Search_ID

40468
Preferred_Name

Recombinant Interferon Beta
prefixIRI

NCIT:C495
prefLabel

Recombinant Interferon Beta
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
UMLS_CUI

C0015980
subClassOf

http://purl.obolibrary.org/obo/NCIT_C584
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