loading...| Preferred Name | Palbociclib | |
| Synonyms |
|
|
| Definitions |
An orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C49176 |
|
| Accepted_Therapeutic_Use_For |
hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative advanced or metastatic breast cancer |
|
| CAS_Registry |
571190-30-2 |
|
| Chemical_Formula |
C24H29N7O2 |
|
| code |
C49176 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
An orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression. |
|
| Display_Name |
Palbociclib |
|
| FDA_UNII_Code |
G9ZF61LE7G |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Palbociclib |
|
| Legacy Concept Name |
PD-0332991 |
|
| Maps_To |
Palbociclib |
|
| NCI_Drug_Dictionary_ID |
454586 |
|
| PDQ_Closed_Trial_Search_ID |
454586 |
|
| PDQ_Open_Trial_Search_ID |
454586 |
|
| Preferred_Name |
Palbociclib |
|
| prefixIRI |
NCIT:C49176 |
|
| prefLabel |
Palbociclib |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C3853822 |
|
| subClassOf |