loading...| Preferred Name | Aprepitant | |
| Synonyms |
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|
| Definitions |
A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C49173 |
|
| ALT_DEFINITION |
A drug used together with other drugs to prevent and control the nausea and vomiting caused by cancer treatment. It is also used to treat nausea and vomiting after surgery. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist. |
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| CAS_Registry |
170729-80-3 |
|
| CHEBI_ID |
CHEBI:499361 |
|
| Chemical_Formula |
C23H21F7N4O3 |
|
| code |
C49173 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors. |
|
| Display_Name |
Aprepitant |
|
| FDA_UNII_Code |
1NF15YR6UY |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Aprepitant |
|
| Legacy Concept Name |
Aprepitant |
|
| NCI_Drug_Dictionary_ID |
454517 |
|
| PDQ_Closed_Trial_Search_ID |
454517 |
|
| PDQ_Open_Trial_Search_ID |
454517 |
|
| Preferred_Name |
Aprepitant |
|
| prefixIRI |
NCIT:C49173 |
|
| prefLabel |
Aprepitant |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C1176306 |
|
| subClassOf |