loading...| Preferred Name |
Alvimopan |
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| Synonyms |
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|
| Definitions |
A synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C49096 |
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| CAS_Registry |
170098-38-1 |
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| Chemical_Formula |
C25H32N2O4.2H2O |
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| code |
C49096 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone. |
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| Display_Name |
Alvimopan |
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| FDA_UNII_Code |
677C126AET |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Alvimopan |
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| Legacy Concept Name |
Alvimopan |
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| NCI_Drug_Dictionary_ID |
453551 |
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| PDQ_Closed_Trial_Search_ID |
453551 |
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| PDQ_Open_Trial_Search_ID |
453551 |
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| Preferred_Name |
Alvimopan |
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| prefixIRI |
NCIT:C49096 |
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| prefLabel |
Alvimopan |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C1508750 |
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| subClassOf |